Comparative study of the release profiles of ibuprofen from polymeric nanocapsules and nanospheres
DOI:
https://doi.org/10.29356/jmcs.v63i2.943Keywords:
ibuprofen, nanotechnology, nanocapsules, nanospheres, release profileAbstract
Abstract. Different carriers were obtained employing the emulsification-diffusion method in order to compare the release profile of a nonsteroidal anti-inflammatory drug from nanocapsules and nanospheres elaborated with Eudragit®. All the batches presented a submicronic particle size, good stability (ζ >30 mV) and the density test confirmed the nanocapsule and nanosphere structure. Evaluation of the release kinetics of ibuprofen using the Korsmeyer-Peppas model evidenced values for the “n” coefficient of 0.799 and 0.816 for nanocapsules and nanospheres, respectively. This indicates that both systems adhere an anomalous diffusion release mechanism that combines drug diffusion and erosion of the polymer.
Resumen. Se obtuvieron diferentes acarreadores mediante el método de emulsificación-difusión con el objetivo de comparar el perfil de liberación de un antiinflamatorio no esteroideo (ibuprofeno) en nanocápsulas y nanoesferas elaboradas con Eudragit®. Todos los lotes obtenidos presentaron un tamaño de partícula submicrónico, adecuada estabilidad (ζ >30 mV) y las pruebas de densidad permitieron confirmar la estructura de los sistemas preparados. La evaluación de la cinética de liberación de ibuprofeno utilizando el modelo de Korsmeyer-Peppas proporcionó coeficientes “n” de 0.799 y 0.816 para nanocápsulas y nanoesferas, respectivamente. Estos valores indican que ambos sistemas presentan un mecanismo de liberación anómalo, que combina los fenómenos de difusión del fármaco y erosión del polímero.
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