Optimization of Extraction Conditions for Flavonoids of Physalis alkekengi var. franchetii Stems by Response Surface Methodology and Inhibition of Acetylcholinesterase Activity

Authors

  • Xue-gui Liu College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Fu-yu Jiang College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Pin-yi Gao College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Mei Jin College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Di Yang College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Zhong-feng Nian College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Zhen-xue Zhang College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning

DOI:

https://doi.org/10.29356/jmcs.v59i1.16

Keywords:

Physalis alkekengi. var. franchetii Stems, Flavonoids, Microwave-assisted Extraction, Response Surface Methodology, Acetylcholinesterase inhibitors

Abstract

The microwave-assisted extraction conditions of flavonoids in Physalis alkekengi. var. franchetii stems were optimized using a L33 Box-Behnken Design. The optimized extraction conditions were determined as follows: 60% for the ethanol concentration, 12.4 for the liquid-to-solid ratio, and 531.4 W for the microwave power, respectively. The yield of the extract obtained under the optimized conditions was 3.85 mg g−1 which was close to the predicted value. In addition, the extract exhibited potent acetylcholinesterase inhibitory activity, with the IC50 value of 11.61 μg mL−1 and a maximal inhibition ratio 89.81%. Both the yield and activity were better than reflux extraction.

Downloads

Download data is not yet available.

References

Zhang, C. H.; Wang, Z. T.; Yang, Y. P.; Sun, S. Q. Chinese Chem. Lett. 2009, 11, 1327-1330.

Matheus, S. S.; Maria, N. de Menezes.; Antoniana, U.; Ivone, M. R.; Therezinha, C. B. T.; Ricardo, Ribeiro dos Santos.; Walter F, de Azevedo.; Milena, B. P. S. J. Agr. Food Chem. 2011, 74, 2269-2272.

Ji, L.; Yuan, Y. L.; Luo, L. P.; Chen, Z.; Ma, X. Q.; Ma, Z. J.; Cheng, L. Steroids. 2012, 5, 441-447.

Zheng, Y. L.; Liu, X. S.; Luan, L. J.; Wang, L. H.; Wu, Y. J. K. J. Chem. Eng. Data. 2010, 55, 3690-3692.

Chen, L. X.; Xia, G. Y.; Liu, Q. Y.; Xie, Y. Y.; Qiu, F. Syst. Ecol. 2014, 54, 31-34.

Qiu, L.; Zhao, F.; Jiang, Z. H.; Chen, L. X.; Zhao, Q.; Liu, H. X.; Yao, X. S.; Qiu, F. J. Nat. Prod. 2008, 71, 642-646.

Hisahiro, K.; Masatsugu, O.; Hiroki, Y.; Wataru, W.; Shigetoshi, T.; Park, Y. K.; Matsuno, K. J.; Yasukawa. K.; Masahiko, K. J.

Funct. Foods. 2014, 5, 214-220.

Alcaraz, M. J.; Hoult, J. R. Biochem. Pharmacol. 1985, 34, 2477-2480.

Divyashree, R.; Amit, K. R.; Francesca, G.; Helen. M. I. O. Int. J. Biochem. Cell. B. 2013, 12, 2821-2829.

Kelly, E. H.; Anthony, R. T.; Dennis, J. B. J. Nutr. Biochem. 2002, 10, 572-584.

Jung, M.; Park, M. S. Molecules. 2007, 12, 2030-2132.

Moon, Y. J.; Wang, X. D.; Morris, M. E. Toxicol. in Vitro. 2006, 20, 187-210.

Pohanka, M.; Jun, D.; Kuca, K. J. Enzym. Inhib. Med.Ch. 2009, 24, 3680-3681.

Sutovsky, S.; Blaho, A.; Kollar, B.; Siarnik, P.; Csefalvay, Z.; Dragasek, J.; Turcani, P. Bratisl. Med. J. 2014, 115, 116-117.

Ibrahim, F.; Andre, C.; Thomassin, M.; Guillaume, Y. C. J. Pharmaceut. Biomed. 2008, 48, 1345-1346.

Zhang, H. F.; Yang, X. H.; Wang Y. Trends. Food Sci. Tech. 2011, 22, 672-682.

Chi, Y. S.; Zhang, Z. D.; Li, C. P.; Liu, Q. S.; Yan, P. F.; Urs, W. B. Green Chem. 2011, 13, 666.

Yadollah, B.; Heshmat, E.; Farshad, F-Far. Org. Process Res. Dev. 12012, 16, 1733-1738.

Xu, W.; Chu, K. D.; Li, H.; Zhang, Y. Q.; Zheng, H. Y.; Chen, R. L.; Chen, L. D. Molecules. 2012, 17, 14331.

Kadam, S. U.; Tiwari, B. K.; O’Donnell, C. P. J. Agr. Food Chem. 2013, 61, 4667?4675.

Winny, R.; Valérie, O. Food Bioprocess Tech. 2012, 5, 409-424.

Wang, L. Z.; Yang, B.; Du, X. Q.; Yi, C. Food Chem. 2008, 108, 737-741.

Liu, Z. G.; Mei, L. J.; Wang, Q. L.; Shao, Y.; Tao. Y. D. LWTFood Sci. Technol. 2014, 56, 171-172.

Zhang, H. W.; Bai, X. L. J. Food Sci. Technol. 2014, 51, 371-376.

Nino, L. R.; Grosseli, G. M.; Mozeto, A. A.; Fadini, P. S. Anal. Methods. 2014, 6, 3247-3253.

Fallarero, A.; Oinonen, P.; Gupta, S.; Blom, P.; Galkin, A.; Mohan, C. G.; Vuorela, P. M. Pharmacol. Res. 2008, 58, 219-221.

Saviana, D. G.; Aline, B.; Aurelie, U.; Andrew, M.; Kurt, H.; Pierre, A. P.; Marianne, R. Eur. J. Pharm. Sci. 2008, 33, 109-111.

Zhang, D. Y.; Yao, X. H.; Duan, M. H.; Luo, M.; Wang, W.; Fu, Y. J.; Zu, Y. G.; Efferth, T. Andr. Analyst. 2013, 138, 4631-

Li, Y. L., Fang, Z. X.; You, J. J. Agr. Food Chem. 2013, 61, 1467-1469.

Kim, M. B.; Park, J. E.; Woo, S. W.; Lim, S. B.; Hwang, J. K. Food Sci. Biotechnol. 2014, 23, 736-738.

Bimakr, M.; Abdul, R. R.; Ganjloo, A.; Taip, F. S.; Salleh, L. M.; Sarker, M. Z. I. Food Bioprocess Tech. 2012, 5, 916-919.

Noe, S-Gonzalez.; Monica, R. J-Fonseca.; Eduardo, S. M-Martinez.; L Gerardo, Z. J. Agr. Food Chem. 2013, 61, 11998-11999.

Mariutti, L. R. B.; Nogueira, G. C.; Bragagnolo, N. J. Agr. Food Chem. 2008, 56, 2913-2918.

Holth, T. F.; Tollefsen, K. E. Aquat. Toxicol. 2012, 112-113, 96-97.

Guo, A. J. Y.; Xie, H. Q.; Choi, R. C. Y.; Zheng, K. Y. Z.; Bi, C. W. C.; Xu, S. L.; Dong, T. T. X.; Tsim, K. W. K. Chem-Biol. Interact. 2010, 187, 246-248.

Downloads

Published

2017-10-12

Issue

Section

Regular Articles

Similar Articles

<< < 1 2 3 4 

You may also start an advanced similarity search for this article.