Optimization of Extraction Conditions for Flavonoids of Physalis alkekengi var. franchetii Stems by Response Surface Methodology and Inhibition of Acetylcholinesterase Activity

Authors

  • Xue-gui Liu College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Fu-yu Jiang College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Pin-yi Gao College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Mei Jin College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Di Yang College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Zhong-feng Nian College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning
  • Zhen-xue Zhang College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning

DOI:

https://doi.org/10.29356/jmcs.v59i1.16

Keywords:

Physalis alkekengi. var. franchetii Stems, Flavonoids, Microwave-assisted Extraction, Response Surface Methodology, Acetylcholinesterase inhibitors

Abstract

The microwave-assisted extraction conditions of flavonoids in Physalis alkekengi. var. franchetii stems were optimized using a L33 Box-Behnken Design. The optimized extraction conditions were determined as follows: 60% for the ethanol concentration, 12.4 for the liquid-to-solid ratio, and 531.4 W for the microwave power, respectively. The yield of the extract obtained under the optimized conditions was 3.85 mg g−1 which was close to the predicted value. In addition, the extract exhibited potent acetylcholinesterase inhibitory activity, with the IC50 value of 11.61 μg mL−1 and a maximal inhibition ratio 89.81%. Both the yield and activity were better than reflux extraction.

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Published

2017-10-12

Issue

Vol. 59 No. 1 (2015): Regular Issue

Section

Regular Articles

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