General Method for Selective Mono-Boc Protection of Diamines and Thereof
Keywords:Chiral, cyclohexane-1, 2-diamine, 1, 2-diphenylethane-1, Boc monoprotection, diamines
AbstractHere we report a simple and efficient protocol for selectively diamine protection with Boc using Me3SiCl or SOCl2 as HCl source in “one-pot” procedure. This methodology is extended to 1,2- to 1,8-diamines to obtain the corresponding mono-Boc protected diamines.
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