General Method for Selective Mono-Boc Protection of Diamines and Thereof

Authors

Felipe Antonio Servín Instituto Tecnológico de Tijuana
José Alfonso Romero Instituto Tecnológico de Tijuana
Gerardo Aguirre Instituto Tecnológico de Tijuana
Douglas Grotjahn San Diego State University
Ratnasamy Somanathan Instituto Tecnológico de Tijuana
Daniel Chávez Instituto Tecnológico de Tijuana

DOI:

https://doi.org/10.29356/jmcs.v61i1.124

Keywords:

Chiral, cyclohexane-1, 2-diamine, 1, 2-diphenylethane-1, Boc monoprotection, diamines

Abstract

Here we report a simple and efficient protocol for selectively diamine protection with Boc using Me₃SiCl or SOCl₂ as HCl source in “one-pot” procedure. This methodology is extended to 1,2- to 1,8-diamines to obtain the corresponding mono-Boc protected diamines.

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Author Biographies

Felipe Antonio Servín, Instituto Tecnológico de Tijuana

Centro de Graduados e Investigación en Química

José Alfonso Romero, Instituto Tecnológico de Tijuana

Centro de Graduados e Investigación en Química

Gerardo Aguirre, Instituto Tecnológico de Tijuana

Centro de Graduados e Investigación en Química

Douglas Grotjahn, San Diego State University

Department of Chemistry and Biochemistry

Ratnasamy Somanathan, Instituto Tecnológico de Tijuana

Centro de Graduados e Investigación en Química

Daniel Chávez, Instituto Tecnológico de Tijuana

Centro de Graduados e Investigación en Química

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Published

2017-10-12

Issue

Vol. 61 No. 1 (2017): Regular Issue

Section

Regular Articles

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