New Pyrone and Quinoline Alkaloid from Almeidea rubra and their Trypanocidal Activity

Authors

  • Alessandra R. P. Ambrozin Universidade Federal de São Carlos
  • Jair Mafezoli Universidade Federal de São Carlos
  • Paulo C. Vieira Universidade Federal de São Carlos
  • João B. Fernandes Universidade Federal de São Carlos
  • M. Fátima das G. F. da Silva Universidade Federal de São Carlos
  • Javier A. Ellena Universidade de São Paulo
  • Sérgio de Albuquerque Universidade de São Paulo

Keywords:

Almeidea rubra, Rutaceae, alkaloids, trypanocidal activity

Abstract

Abstract. The investigation of the ethyl acetate fraction of methanol extract from leaves of Almeidea rubra A. St.-Hil. (Rutaceae) afforded two new compounds 4-methoxy-6-[2-(methylamino)phenyl]-2H-pyran-
2-one and rel-(7R,8R)-8-[(E)-3-hydroxy-3-methyl-1-butenyl]-4,8-dimethoxy-5,6,7,8-tetrahydrofuro[2,3-b]quinoline-7-yl acetate, along with the known compounds arborinine, N-methyl-1-hydroxy-3-methoxyacridone, skimmianine, kokusagine, isodutaduprine, isoskimmianine, and isokokusagine. Their structures were established based on their spectral data, and for the new compounds these data are described herein. Additionally, these compounds were assayed on the tripomastigote forms of Trypanosoma cruzi showing moderate trypanocidal activity.

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Author Biographies

Alessandra R. P. Ambrozin, Universidade Federal de São Carlos

Departamento de Química

Jair Mafezoli, Universidade Federal de São Carlos

Departamento de Química

Paulo C. Vieira, Universidade Federal de São Carlos

Departamento de Química

João B. Fernandes, Universidade Federal de São Carlos

Departamento de Química

M. Fátima das G. F. da Silva, Universidade Federal de São Carlos

Departamento de Química

Javier A. Ellena, Universidade de São Paulo

Instituto de Física de São Carlos

Sérgio de Albuquerque, Universidade de São Paulo

Departamento de Análises Clínicas, Toxicológicas, Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto

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Published

2020-08-07

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Regular Articles