Synthesis of (E)-(4-(Aryl)phenyl)(3-(2-(1-phenyl-3-(thiophen-2-yl)-1Hpyrazol-4-yl)vinyl)benzofuran-2-yl)methanones by Claisen Schmidt-Suzuki Cross Coupling and their Antibacterial and Antifungal Activity

Authors

  • Ashok Dongamanti Osmania University
  • Mohammad Ziauddin Osmania University
  • Bommidi Vijaya Lakshmi Osmania University
  • Madderla Sarasija Osmania University

DOI:

https://doi.org/10.29356/jmcs.v61i3.342

Keywords:

Aromatic boronic acid, Antimicrobial activity, Microwave irradiation, Claisen-Schimdt, Suzuki cross-coupling reaction

Abstract

A series of ten novel (E)-(4-(aryl)phenyl)(3-(2-(1-phenyl-3- (thiophen-2-yl)-1H-pyrazol-4-yl)vinyl)benzofuran-2-yl)methanones (7a-j) derivatives were prepared by traditional Claisen-Schmidt and Suzuki cross-coupling reaction under conventional and microwave irradiation conditions. The structures of all the newly synthesized compounds were established on the basis of FTIR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. The products were assayed for their in vitro antibacterial activity against different types of bacterial strains. Further the antifungal activity was examined by inhibitory action against three fungal strains such as Aspergillus niger, Aspergillus flavus and Fusarium oxysporum.

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Author Biographies

Ashok Dongamanti, Osmania University

Green and Medicinal Chemistry laboratory, Department of Chemistry

Mohammad Ziauddin, Osmania University

  1. Green and Medicinal Chemistry laboratory, Department of Chemistry
  2. Department of pharmaceutical Sciences, University College of technology

Bommidi Vijaya Lakshmi, Osmania University

Green and Medicinal Chemistry laboratory, Department of Chemistry

Madderla Sarasija, Osmania University

Green and Medicinal Chemistry laboratory, Department of Chemistry

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Published

2017-10-26

Issue

Vol. 61 No. 3 (2017): Regular Issue

Section

Regular Articles

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