Spectroscopic Characterization of an Oxovanadium(IV) Complex of Oxodiacetic Acid and 2,2’-Bipyridine. Bioactivity on Osteoblast-Like Cells in Culture

Authors

  • Ignacio E. León Universidad Nacional de La Plata
  • Susana B. Etcheverry Universidad Nacional de La Plata
  • Beatriz S. Parajón-Costa Universidad Nacional de La Plata
  • Enrique J. Baran Universidad Nacional de La Plata

DOI:

https://doi.org/10.29356/jmcs.v57i3.204

Keywords:

Oxovanadium(IV), oxodiacetic acid, 2, 2’-bipyridine, vibrational spectra, electronic spectra, osteoblast cells in culture, antitumoral action.

Abstract

The oxovanadium(IV) complex of oxodiacetic acid (H2ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H2O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]⋅H2O can be considered as a good candidate to be further investigated in relation to cancer treatment.

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Author Biographies

Ignacio E. León, Universidad Nacional de La Plata

  1. Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas
  2. Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas

Susana B. Etcheverry, Universidad Nacional de La Plata

  1. Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas
  2. Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas

Beatriz S. Parajón-Costa, Universidad Nacional de La Plata

Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas

Enrique J. Baran, Universidad Nacional de La Plata

Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas

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Published

2017-10-12

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