Liquid Chromatography for the Analysis of Hydrophilic Drugs in the Presence of Ionic Liquids

Authors

  • Marsela Garza Tapia Universidad Autónoma de Nuevo León
  • Abelardo Chávez Montes Universidad Autónoma de Nuevo León
  • Encarnación Moyano Morcillo Universidad de Barcelona
  • Ma. Teresa Galceran i Huguet Universidad de Barcelona
  • Noemí H. Waksman de Torres Universidad Autónoma de Nuevo León
  • Rocío Castro Ríos Universidad Autónoma de Nuevo León

DOI:

https://doi.org/10.29356/jmcs.v58i1.151

Keywords:

Ionic liquids, HPLC, hydrophilic interaction chromatography, drugs, hydrophilic compounds

Abstract

Currently available methods for the analysis of hydrophilic compounds are usually time-consuming, tedious and inefficient. Ionic liquids (ILs) are salts with low melting points that are described as designer solvents. When ILs are used in the extraction of hydrophilic compounds, liquid chromatographic analysis can be challenging, as a result of co-elution of the IL with the analyte and poor miscibility of the IL with the mobile phase. This paper describes the development of analytical methods for hydrophilic compounds in the presence of water-immiscible ILs. Conventional and ion-pair reversed phase and hydrophilic interaction liquid chromatography were tested, with the best results obtained with the last one. The proposed methods showed a good performance and represent a useful alternative for the analysis of hydrophilic drugs.

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Author Biographies

Marsela Garza Tapia, Universidad Autónoma de Nuevo León

Departamento de Química Analítica, Facultad de Medicina

Abelardo Chávez Montes, Universidad Autónoma de Nuevo León

Departamento de Química, Facultad de Ciencias Biológicas

Encarnación Moyano Morcillo, Universidad de Barcelona

Departamento de Química Analítica, Facultad de Química

Ma. Teresa Galceran i Huguet, Universidad de Barcelona

Departamento de Química Analítica, Facultad de Química

Noemí H. Waksman de Torres, Universidad Autónoma de Nuevo León

Departamento de Química Analítica, Facultad de Medicina

Rocío Castro Ríos, Universidad Autónoma de Nuevo León

Departamento de Química Analítica, Facultad de Medicina

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Published

2017-10-12

Issue

Vol. 58 No. 1 (2014): Regular Issue

Section

Regular Articles

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