A Green Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones via One-Pot Multi-Component Reaction by Using Cuttlebone as a Natural Catalyst under Solvent-Free Conditions

  • Nooshin Firoozeh Islamic Azad University
  • Soodabeh Rezazadeh Islamic Azad University
  • Cobra Izanloo Islamic Azad University
Keywords: Cuttlebone, 3, 4-dihydropyrimidin-2(1H)-ones, aldehydes, one-pot reaction, green

Abstract

In this paper, an efficient, green and eco-friendly method for synthesis of 3,4-dihydropyrimidin-2(1H)-ones via one-pot multi-component reaction of aldehydes, urea and ethyl acetoacetate is shown at the presence of cuttlebone as an effective, reusable and natural heterogeneous catalyst. The advantages of this method are short reaction times, high yields, simple work-up, and reusable natural catalysts. The structure of cuttlebone was characterized by FT-IR spectrum, scanning electron microscopy (SEM) and energy dispersive spectrometer (SEM-EDS).

Author Biographies

Nooshin Firoozeh, Islamic Azad University
Department of Chemistry, Faculty of Sciences, Bojnourd Branch
Soodabeh Rezazadeh, Islamic Azad University
Department of Chemistry, Faculty of Sciences, Bojnourd Branch
Cobra Izanloo, Islamic Azad University
Department of Chemistry, Faculty of Sciences, Bojnourd Branch
Published
2017-10-26