Cytotoxic and Anti-inflammatory Constituents from Juncus effusus
DOI:
https://doi.org/10.29356/jmcs.v60i2.78Keywords:
Juncus effusus, chemical constituent, cytotoxic activity, anti-inflammatory activityAbstract
A new sesquilignan effususin E (1) and a new long chain fatty enamide effususin F (2), together with eight known compounds were isolated from the medullae of Juncus effusus. The structures of 1 and 2 were elucidated by detailed spectroscopic analysis including 1H and 13C NMR, COSY, HSQC, HMBC, and HRMS, while the struc-tures of the known compounds were deduced from comparison of their spectral data with those in the literature. The new compounds 1 and 2 were evaluated against five human cancer cell lines (SHSY-5Y, SMMC-7721, HepG-2, Hela, and MCF-7) by CCK-8 assay, but only 1 exhibited weak cytotoxic activity against SMMC-7721 with IC50 val-ue of 57.5 μM. Inhibitory effects of 1 and 2 on nitric oxide (NO) pro-duction in lipopolysaccharide-induced RAW264.7 macrophages were also evaluated, and they were found to exhibit good inhibitory activities with IC50 values of 8.59 and 13.73 μM, respectively.
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