Chemical Speciation of the Fe(III)-piroxicam and Fe(III)-tenoxicam Systems in Aqueous Solution
DOI:
https://doi.org/10.29356/jmcs.v55i2.838Keywords:
Fe(III), tenoxicam, piroxicam, SQUAD, chemical speciation.Abstract
A chemical speciation study of the antiinflamatory drugs piroxicam and tenoxicam was carried out with the Fe(III) ion, under pseudophysiological conditions (T = 37ºC and I = 0.15 M). The equilibrium constants for the formation of the Fe(III)-oxicam species were obtained from UV/VIS spectrophotometric data assisted by SQUAD program. The hydrolysis constants of Fe(III) were also refined under the same experimental conditions. For tenoxicam, the constants refined correspond to the species Fe(H2tenox)2 5+, Fe(Htenox)2 3+, Fe(OH)2(Htenox) 2+, Fe(OH)2(tenox)2 -, FeH2tenox 4+, FeHtenox 3+, Fe(OH)2Htenox + and Fe(OH)2tenox, an analogous model was established to refine the piroxicam constants. The molar absorptivity coefficients for all the species were also calculated.
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References
Neilands, J. B., in: Microbial Iron Metabolism, Neilands, J. B., Ed., Academic Press, New York, USA, 1974, 3-34.
Ochiai, E. I. Química Bioinorgánica: Una Introducción. Reverté, Barcelona, 1985, 103-123.
Raymond, K. N.; Garrett T. Pure & Appl. Chem. 1988, 60, 12, 1807-1816.
Carrano, C. J.; Raymond, K. N. J. Am. Chem. Soc. 1979, 101, 5401-5404.
Harris, W. R., in: Molecular and Cellular Iron Transport, Templeton D. M., Ed., Marcel Dekker, Inc., New York, 2002, 1-40.
Kaim, W.; Schwederski, B. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life an Introduction and Guide.
Wiley and Sons, New York, USA, 1994, 150-171.
Guo, Z.; Sadler, P. J. Angew. Chem. Int. Ed. 1999, 38, 1512-1531.
Sayah A.; English J. C. J. Am. Acad. Dermatol. 2005, 53, 2, 191-209.
Defazio, S.; Cini, R. J. Chem. Soc., Dalton Trans. 2002, 1888-1897.
Dubler, E. Biochemical and Pharmaceutical Aspects of Metal Complexation by Drugs, in: Metal ions in Biological Systems,Vol. 32, Sigel, A.; Sigel, H., Eds., Marcel Dekker, New York, 1996, 301-338.
Jackson, G. E.; May, P. M.; Williams, D. H. J. Inorg. Nucl. Chem. 1978, 40, 1189-1194.
Fiabane, A. M.; Williams, D. R. J. Inorg. Nucl. Chem. 1978, 40, 1195-1200.
Micheloni, M.; May, P. M.; Williams, D. R. J. Inorg. Nucl. Chem. 1978, 40, 1209-1219.
Arena, G.; Kavu, G.; Williams, D. R. J. Inorg. Nucl. Chem. 1978, 40, 1221-1226.
Jackson, G. E.; May, P. M.; William, D. R. J. Inorg. Nucl. Chem. 1978, 40, 1227-1234.
Bury, A.; Underhill, A. E.; Kemp, D. R.; O’Shea, N. J.; Smith, J. P.; Gomm, P. S. Inorg. Chim. Acta 1987, 138, 85-89.
Pipe, D. A.; MacBrayne, J. C.; Gomm, P. S.; Graham, A. W.; Allan, U. E.; Gomm, R. J. P. Gazz. Chim. Ital. 1994, 124, 463-466.
Moya-Hernández, R.; Gómez-Balderas, R.; Mederos, A.; Domínguez, S.; Ramírez-Silva, M. T.; Rojas-Hernández, A. J. Coord. Chem. 2009, 62, 1, 40-51.
Baes, C. F.; Mesmer, R. E. The hydrolysis of cations. Wiley, New York, 1976, 229-237.
Leggett, D. J., in: Computational Methods for the Determination of Formation Constants, Leggett, D. J., Ed., Plenum Press, New York, 1985, 159-220.
Byrne, R.; Yao, W.; Luo, Y.-R.; Wang, B. Marine Chem., 2005, 97, 34-48.
Moya-Hernández, M. R.; Mederos, A.; Domínguez, S.; Orlandini, A.; Ghilardi, C. A.; Cecconi, F.; González-Vergara, E.; Rojas-Hernández, A. J. Inorg. Biochem. 2003, 95, 131-140.
Puigdomenech I., Make Equilibrium Diagrams Using Sofisticated Algorithms (MEDUSA), 2009, www.kemi.kth.se/medusa (last visit 07/05/2011).
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