Synthesis of Dialkyl 2-(4-oxopyridin-1(4H)-yl)dicarboxylates Through the Reaction of 4-hydroxypyridine and Dialkyl Acetylenedicarboxylate in the Presence of Triphenylphosphine
DOI:
https://doi.org/10.29356/jmcs.v55i3.827Keywords:
4-Hydroxypyridine, dialkyl acetylenedicarboxylates, triphenylphosphine, dialkyl 2-(4-oxopyridin-1(4H)-yl)but-2-enedioates.Abstract
4-Hydroxypyridine undergoes a smooth reaction with dialkylacetylenedicarboxylates in the presence of triphenylphosphine (15
mol %) to produce the E/Z isomers of dialkyl 2-(4-oxopyridin-1(4H)-yl)but-2-enedioates in high yields.
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