Synthesis of New Bicyclic Hydroxamic Acids with Cytotoxic Activity

  • Iker S. Escalona-Torres Universidad Nacional Autónoma de México
  • Francisco Yuste Universidad Nacional Autónoma de México
  • Rubén Sánchez-Obregón Universidad Nacional Autónoma de México
Keywords: Hydroxamic acids, Michael addition, nitro group rearrangement, cytotoxic activity

Abstract

Six new bicyclic hydroxamic acids were synthesized through an uncommon nitro group rearrangement between β-nitrostyrenes and dimedone. The structures of all the new synthesized compounds were confirmed using a combination of FTIR, 1H NMR, 13C NMR and mass spectral data. Likewise, the cytotoxic activity of the obtained products was evaluated in six different cancer cell lines. Two compounds showed significant potency on two cancer cell lines with IC50 between 9.31±0.1 and 23.38±0.9 μM.

Author Biographies

Iker S. Escalona-Torres, Universidad Nacional Autónoma de México
Instituto de Química
Francisco Yuste, Universidad Nacional Autónoma de México
Instituto de Química
Rubén Sánchez-Obregón, Universidad Nacional Autónoma de México
Instituto de Química

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Published
01-30-2018