Microwave Assisted One Pot Synthesis of Tetrazole Based 3-hydroxy-4H-chromen-4-ones by modified Algar-Flynn-Oyamada reaction and their Antimicrobial activity

Authors

  • ASHOK DONGAMANTI Osmania University
  • Nagaraju Nalaparaju Osmania University
  • Sarasija Madderla Satavahana University
  • Vijaya Lakshmi Bommidi Osmania University

DOI:

https://doi.org/10.29356/jmcs.v63i4.448

Keywords:

2-hydroxy acetophenone, 4-(1H-tetrazol-5-yl) benzaldehyde, microwave irradiation, antimicrobial activity.

Abstract

In the present work, we report the one pot synthesis of tetrazole based 3-hydroxy-4H-chromen-4-ones 3(a-g) from  4-(1H-tetrazol-5-yl)benzaldehyde and 2-hydroxy acetophenone using KOH and H2O2 by modified Algar-Flynn-Oyamada reaction under conventional and microwave irradiation conditions. In this technique, flavonols are synthesized without isolating chalcones, in good yields. All the synthesized compounds were characterized by IR, NMR, MS and elemental. All newly synthesized compounds were screened for their in-vitro antimicrobial activity against strains such as Staphylococcus aurous, Bacillus subtilis, Klebsiella pneumonia, Escherichia coli, Aspergillus Niger, Aspergillus flavus, and Fusarium oxysporum. The results of antimicrobial studies revealed that most of the compounds exhibit good activity.

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Author Biographies

ASHOK DONGAMANTI, Osmania University

Green and Medicinal Chemistry laboratory, Department of Chemistry

Nagaraju Nalaparaju, Osmania University

Green and Medicinal Chemistry laboratory, Department of Chemistry

Sarasija Madderla, Satavahana University

Department of Chemistry

Vijaya Lakshmi Bommidi, Osmania University

Green and Medicinal Chemistry laboratory

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Published

2019-12-09

Issue

Vol. 63 No. 4 (2019): Regular Issue

Section

Regular Articles

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