DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-β-amino alcohol Schiff bases

Authors

  • Turgay Tunç Department of Chemistry Engineering and Process, Faculty of Engineering, University of Ahi Evran, K?rsehir
  • Nadir Demirel Department of Chemistry, Faculty of Science & Art, University of Ahi Evran, K?rsehir
  • Mahmut Emir Department of Chemistry, Faculty of Science & Art, University of Ahi Evran, K?rsehir
  • Asl?han Günel Department of Chemistry, Faculty of Science & Art, University of Ahi Evran, K?rsehir
  • Mehmet Çolak Department of Chemistry.; Faculty of Science.; University of Dicle.; Diyarbak?r
  • Nurcan Karacan Department of Chemistry.; Faculty of Science.; University of Gazi.; Ankara

DOI:

https://doi.org/10.29356/jmcs.v62i3.424

Keywords:

Copper (II) complexes, DFT calculations, DNA binding, DNA cleavage, Schiff base complexes.

Abstract

Abstract. Three new copper(II) complexes (1-3) with general formula [Cu(HL)CH3COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized.  Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants Kb were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA.

 

Resumen. Tres nuevos complejos de cobre (II) (1-3) con la fórmula general [Cu (HL) CH

3COO] de N-salicil-β-amino alcohol Schiff bases que contienen, (S) - (+) - fenilglicinol, (1S, 2R). Se sintetizaron -2-amino-1, 2-difeniletanol y 1, 1, 3-trifenil- (R) - (+) - 2-amino propanol. Sus estructuras se caracterizaron por FTIR, LCMS, momento magnético, conductancia molar y datos de análisis elemental. Los cálculos de DFT propusieron geometrías planas cuadradas distorsionadas para los complejos. Los espectros de IR calculados están en buena concordancia con los espectros de IR experimentales, confirmando las estructuras propuestas. Se investigaron sus interacciones con el ADN del timo de ternera y se encontraron sus constantes de unión Kb. La electroforesis en gel revela que todos los complejos muestran una actividad nucleasa significativa contra el ADN plasmídico pentry / d-topo superenrollado.

 

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Published

2019-04-22

Issue

Vol. 62 No. 3 (2018): Regular Issue

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Regular Articles

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