One-pot, three-component synthesis of pyrrolo[2,3-d]pyrimidine derivatives
DOI:
https://doi.org/10.29356/jmcs.v62i1.340Keywords:
1, 3-Dimethyl-6-aminouracil, Arylglyoxals, Barbituric acid derivatives, TBAB, Pyrrolo[2, 3-d]pyrimidine, One-pot .Abstract
A green approach for the synthesis of polyfunctionalized pyrrolo[2,3-d]pyrimidine derivatives was successfully achieved by a one-pot, three-component reaction of arylglyoxals, 6-amino-1,3-dimethyluracil and barbituric acid derivatives in the presence of tetra-n-butylammonium bromide (TBAB) (5 mol%) as the catalyst in ethanol at 50 °C. This protocol has many advantages such as high yields (73-95%), green and simple procedure, short reaction times, easy work-up, mild reaction conditions and general applicability.
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