Diligustilide: Enantiomeric Derivatives, Absolute Configuration and Cytotoxic Properties

Authors

  • Alejandra León Universidad Nacional Autónoma de México
  • Guillermo Delgado Universidad Nacional Autónoma de México

DOI:

https://doi.org/10.29356/jmcs.v56i2.326

Keywords:

Ligusticum porteri, diligustilide, enantiopure derivatives, electronic circular dichroism, exciton chirality method, cytotoxicity

Abstract

New enantiomeric amides (-)-6, (+)-7, (+)-6, and (-)-7 were formed by the reaction of the natural dimeric phthalide rac-diligustilide (rac-1) with (R)-(+)-α-methylbenzylamine and (S)-(-)- α-methylbenzylamine. The absolute configurations of compounds 6 and 7 were assigned by the analysis of electronic circular dichroism curves by means of the exciton chirality method. Compounds 1, 4, 5, (-)-6, (+)-6, (+)-7, and (-)-7 exhibited cytotoxic activity towards several human tumor cell lines.

Downloads

Download data is not yet available.

Author Biographies

Alejandra León, Universidad Nacional Autónoma de México

Instituto de Química

Guillermo Delgado, Universidad Nacional Autónoma de México

Instituto de Química

Downloads

Published

2017-10-12

Issue

Section

Regular Articles

Most read articles by the same author(s)

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.