Microwave-assisted High Diastereoselective Synthesis of α-Aminophosphonates under Solvent and Catalyst Free-conditions

Authors

  • Gaurao D. Tibhe Universidad Autónoma del Estado de Morelos
  • Miguel Angel Reyes-González Universidad Autónoma del Estado de Morelos
  • Carlos Cativiela Universidad de Zaragoza-CSIC
  • Mario Ordóñez Universidad Autónoma del Estado de Morelos

DOI:

https://doi.org/10.29356/jmcs.v56i2.319

Keywords:

Three-component Reaction, Diastereoselective Synthesis, α-aminophosphonates, Microwave, Green-Chemistry

Abstract

A simple, efficient and general method has been developed for the high diastereoselective synthesis of α-aminophosphonates through “one-pot” three-component reaction of alkyl and aryl aldehydes with (S)-α-methylbenzylamine or (S)-3,3-dimethyl-2-butylamine and dimethyl phosphite (Kabachnik-Fields reaction), which proceeds in short time using microwave irradiation under solvent and catalyst free-conditions. This method could be useful in the large-scale synthesis of α-aminophosphonates in short reaction time

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Author Biographies

Gaurao D. Tibhe, Universidad Autónoma del Estado de Morelos

Centro de Investigaciones Químicas

Miguel Angel Reyes-González, Universidad Autónoma del Estado de Morelos

Centro de Investigaciones Químicas

Carlos Cativiela, Universidad de Zaragoza-CSIC

Departamento de Química Orgánica, ISQCH

Mario Ordóñez, Universidad Autónoma del Estado de Morelos

Centro de Investigaciones Químicas

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Published

2017-10-12

Issue

Vol. 56 No. 2 (2012): Regular Issue

Section

Regular Articles

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