Antigiardial Activity of Cupania dentata Bark and its Constituents
DOI:
https://doi.org/10.29356/jmcs.v56i2.305Keywords:
Cupania dentata, Sapindaceae, giardicidal activity, taraxerone, taraxerol, scopoletin, sterolsAbstract
The MeOH extract of Cupania dentata bark (Sapindaceae) as well as its hexane, CH2Cl2, EtOAc, and BuOH fractions showed high activity against Giardia lamblia trophozoites (IC50 = 2.12-9.52 μg/mL). The phytochemical study of fractions resulted in the isolation of taraxerone (1), taraxerol (2), scopoletin (3), and two mixtures of steroidal compounds. Taraxerone was the metabolite with the highest giardicidal activity (IC50 = 11.33 μg/mL).Downloads
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Published
2017-10-12
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