Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides
DOI:
https://doi.org/10.29356/jmcs.v59i2.26Keywords:
Triazoles, phenylboronic acid, CuSO4, Microwave irradiationAbstract
The synthesis of 1,4-disubstituted-1,2,3-triazoles from alkyl azides and terminal alkynes at room temperature and under microwave heating was attained using Cu(I), generated in-situ from copper(II) sulfate and phenylboronic acid, as catalyst. Twelve new triazoles were obtained in moderate to good yields (53-98%), and the products were obtained by crystallization from the mixture reaction without further purification.
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X-ray crystallographic data (excluding structure factors) for the structures in this paper has been deposited with the Cambridge Crystallographic Data Centre as a Supplementary Publication Numbers, CCDC 1007167 No. for 3f, CCDC 1007170 No. for 4, CCDC 1007168 No. for 3h, and CCDC 1007169 No for 3j. Copy of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44(0) 1223 336033 or e-mail: deposit@ccdc.cam.ac.uk].
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