Essential Metal-based drugs: Correlation between Redox Potential and Biological Activity of M2+ with a N2O2 Ligand

Authors

  • Arturo Verduzco-Ramírez Universidad Nacional Autónoma de México
  • Silvia Graciela Manzanilla-Dávila Universidad Nacional Autónoma de México
  • María Eugenia Morales-Guillén Universidad Nacional Autónoma de México
  • Juan Carlos García-Ramos Universidad Nacional Autónoma de México
  • Yanis Toledano-Magaña Universidad Nacional Autónoma de México
  • Armando Marin-Becerra Universidad Nacional Autónoma de México
  • Marcos Flores-Álamo Universidad Nacional Autónoma de México
  • Luis Antonio Ortiz-Frade Centro de Investigación y Desarrollo Tecnológico en Electroquímica S.C.
  • Luis Fernando Olguín-Contreras Universidad Nacional Autónoma de México
  • Lena Ruiz-Azuara Universidad Nacional Autónoma de México

DOI:

https://doi.org/10.29356/jmcs.v61i2.258

Keywords:

2, 9-biformyl-4, 7-biphenyl-1, 10-phenanthroline, reduction, oxidation, inhibitory, IC50

Abstract

One of the major public health problems worldwide is cancer followed by a significant number of deaths due to the resistance developed by bacteria or protozoan to the currently employed treatments. This generates an immediate need to develop drugs to treat these afflictions (illnesses, diseases). It has recently been identified that tumor cell, bacteria or protozoa are quite sensitive to oxidative stress induced by the same drugs. Due to this, it is important to develop new drugs to attend them, in this case, by using metals to increase the concentration of oxidative species. In the present work, the ligand 2,9-diformyl-4,7-diphenyl-1,10-phenanthroline and its corresponding coordination compounds with essential metals such as iron(II), cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized. The electrochemical study shows that these compounds present three redox processes, all of them associated to the ligand. The compounds have shown inhibitory activity in vitro against human neuroblastoma CHP-212 cells, Escherichia coli and trophozoites of Entamoeba histolytica HM1:IMSS. It has been found that the inhibitory activity of the compounds studied is related to the first reduction process of the ligand. The correlation between the inhibitory activity and the red ox potential was linear. The inhibitory activity in CHP-212 increased with the increase of the compounds’ redox potential values, in contrast with the behavior observed in Escherichia coli, where the compounds with lowest redox potential values have had significantly higher inhibitory activity. Many of these coordination compounds have shown a higher inhibitory activity than those typically used in the treatment of cancer (cisplatin). The next step is to prove these compounds in vitro against healthy cells in order to verify its selectivity or cytotoxicity in these systems.

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Author Biographies

Arturo Verduzco-Ramírez, Universidad Nacional Autónoma de México

Departamento de Química Inorgánica y Nuclear, Facultad de Química

Silvia Graciela Manzanilla-Dávila, Universidad Nacional Autónoma de México

Departamento de Química Inorgánica y Nuclear, Facultad de Química

María Eugenia Morales-Guillén, Universidad Nacional Autónoma de México

Departamento Fisicoquímica, Facultad de Química

Juan Carlos García-Ramos, Universidad Nacional Autónoma de México

Departamento de Química Inorgánica y Nuclear, Facultad de Química

 

‡ Currently as postdoctoral fellow at Instituto de Química, UNAM.

Yanis Toledano-Magaña, Universidad Nacional Autónoma de México

Departamento de Química Inorgánica y Nuclear, Facultad de Química

 

§ Currently at Centro de Nanociencia y Nanotecnología, UNAM

Armando Marin-Becerra, Universidad Nacional Autónoma de México

Departamento de Química Inorgánica y Nuclear, Facultad de Química

Marcos Flores-Álamo, Universidad Nacional Autónoma de México

Departamento de Química Inorgánica y Nuclear, Facultad de Química

Luis Antonio Ortiz-Frade, Centro de Investigación y Desarrollo Tecnológico en Electroquímica S.C.

Electrochemistry Department

Luis Fernando Olguín-Contreras, Universidad Nacional Autónoma de México

Departamento Fisicoquímica, Facultad de Química

Lena Ruiz-Azuara, Universidad Nacional Autónoma de México

Departamento de Química Inorgánica y Nuclear, Facultad de Química

Published

2017-10-12