A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells

Authors

  • Myrna Luna-Gutiérrez 1. Instituto Nacional de Investigaciones Nucleares 2. Universidad Autónoma del Estado de México
  • Guillermina Ferro-Flores Instituto Nacional de Investigaciones Nucleares
  • Blanca E. Ocampo-García Instituto Nacional de Investigaciones Nucleares
  • Clara L. Santos- Cuevas Instituto Nacional de Investigaciones Nucleares
  • Nallely Jiménez-Mancilla 1. Instituto Nacional de Investigaciones Nucleares 2. Universidad Autónoma del Estado de México
  • L. M De León-Rodríguez Universidad de Guanajuato
  • Erika Azorín-Vega Instituto Nacional de Investigaciones Nucleares
  • Keila Isaac- Olivé Universidad Autónoma del Estado de México

DOI:

https://doi.org/10.29356/jmcs.v57i3.209

Keywords:

gold nanoparticles, radiolabeled nanoparticles, radio-gold nanoparticles, radiolabeled peptides, nanoparticle-peptide, RGD peptide, lutetium-177

Abstract

The aim of this research was to evaluate the in vitro potential of 177Lu-labeled gold nanoparticles conjugated to cyclo-[RGDfK(C)] peptides (177Lu-AuNP-c[RGDfK(C)]) as a plasmonic photothermal therapy and targeted radiotherapy system in MCF7 breast cancer cells. Peptides were conjugated to AuNPs (20 nm) by spontaneous reaction with the thiol group of cysteine (C). After laser irradiation, the presence of c[RGDfK(C)]-AuNP in cells caused a significant increase in the temperature of the medium (50.5 °C, compared to 40.3 °C without AuNPs) resulting in a significant decrease in MCF7 cell viability down to 9 %. After treatment with 177-AuNP-c[RGDfK(C)], the MCF7 cell proliferation was significantly inhibited.

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Author Biographies

Myrna Luna-Gutiérrez, 1. Instituto Nacional de Investigaciones Nucleares 2. Universidad Autónoma del Estado de México

  1. Departamento de Materiales Radiactivos
  2. Facultad de Medicina

Guillermina Ferro-Flores, Instituto Nacional de Investigaciones Nucleares

Departamento de Materiales Radiactivos

Blanca E. Ocampo-García, Instituto Nacional de Investigaciones Nucleares

Departamento de Materiales Radiactivos

Clara L. Santos- Cuevas, Instituto Nacional de Investigaciones Nucleares

Departamento de Materiales Radiactivos

Nallely Jiménez-Mancilla, 1. Instituto Nacional de Investigaciones Nucleares 2. Universidad Autónoma del Estado de México

  1. Departamento de Materiales Radiactivos
  2. Facultad de Medicina

L. M De León-Rodríguez, Universidad de Guanajuato

Departamento de Química

Erika Azorín-Vega, Instituto Nacional de Investigaciones Nucleares

Departamento de Materiales Radiactivos

Keila Isaac- Olivé, Universidad Autónoma del Estado de México

Facultad de Medicina

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Published

2017-10-12

Issue

Vol. 57 No. 3 (2013): Special Issue on Bioinorganic Chemistry

Section

Regular Articles

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