One-Pot Synthesis of 1,8-Dioxodecahydroacridines and Polyhydroquinoline using 1,3-Di (bromo or chloro)-5,5-Dimethylhydantoin as a Novel and Green Catalyst under Solvent-Free Conditions

  • Behrooz Maleki Hakim Sabzevari University
  • Reza Tayebee Hakim Sabzevari University
  • Mina Kermanian Hakim Sabzevari University
  • Samaneh Sedigh Ashrafi Hakim Sabzevari University
Keywords: Aldehydes, cyclic 1, 3-dicarbonyl compounds, ammonium acetate, ethyl acetoacetate, green catalyst, solvent-free conditions, onepot synthesis

Abstract

Solvent-free, one-pot synthesis of polyhdroquinoline and 1,8-dioxodecahydroacridine derivatives have been described via Hantzsch condensation of various aldehydes, ammonium acetate with (i) cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate and (ii) cyclic 1,3-dicarbonyl compounds (2 mmoles) in a very simple, efficient, and environmentally benign method using 1,3-(dibromo or dichloro)-5,5-dimethylhydantoin as a cheap, non-toxic and neutral catalyst with up to excellent yields.

Author Biographies

Behrooz Maleki, Hakim Sabzevari University
Department of Chemistry
Reza Tayebee, Hakim Sabzevari University
Department of Chemistry
Mina Kermanian, Hakim Sabzevari University
Department of Chemistry
Samaneh Sedigh Ashrafi, Hakim Sabzevari University
Department of Chemistry
Published
10-12-2017