Efficient Synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide Process

Authors

  • Luis Edilberto Cárdenas-Galindo Universidad de Guanajuato
  • Alejandro Islas-Jácome Universidad de Guanajuato
  • Carlos Jesús Cortes-García Universidad de Guanajuato
  • Laurent El Kaim Ecole Nationale Supérieure de Techniques Avancées
  • Rocío Gámez-Montaño Universidad de Guanajuato

DOI:

https://doi.org/10.29356/jmcs.v57i4.191

Keywords:

Multicomponent reactions, Ugi-azide, 1, 5 dipolar electrocyclization, tetrazole, azide, isocyanide

Abstract

A series of eighteen novel 1,5-disubstituted-1H-tetrazoles has been prepared with moderate to good overall yields using an Ugi-azide reaction as key step under mild conditions. Tetrazoles are heterocyclic systems present in several synthetic products which have privileged biological activity. Therefore, in this paper we describe the synthesis of novel compounds containing the tetrazole moiety, which could present biological activity.

Downloads

Download data is not yet available.

Author Biographies

Luis Edilberto Cárdenas-Galindo, Universidad de Guanajuato

Departamento de Química, División de Ciencias Naturales y Exactas

Alejandro Islas-Jácome, Universidad de Guanajuato

Departamento de Química, División de Ciencias Naturales y Exactas

Carlos Jesús Cortes-García, Universidad de Guanajuato

Departamento de Química, División de Ciencias Naturales y Exactas

Laurent El Kaim, Ecole Nationale Supérieure de Techniques Avancées

Laboratoire Chimie et Procédés

Rocío Gámez-Montaño, Universidad de Guanajuato

Departamento de Química, División de Ciencias Naturales y Exactas

Downloads

Published

2017-10-12

Issue

Section

Regular Articles

Most read articles by the same author(s)