Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril

Authors

  • M. Zaky Zagazig University
  • Mohamed Y. El-Sayed 1. Zagazig University 2. Al Jouf University-Al Qurayate
  • Samy M. El-Megharbel 1. Zagazig University 2. Taif University
  • Sameh Abo Taleb Zagazig University
  • Moamen S. Refat 1. Taif University, Sauidi Arabia 2. Port Said University, Egypt

DOI:

https://doi.org/10.29356/jmcs.v58i2.170

Keywords:

Lisinopril complexes, Infrared spectra, electronic spectra, thermal analysis, antimicrobial activity

Abstract

Complexes of lisinopril as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III) and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The lisinopril ligand acts as a monodentate feature via one carboxylate oxygen atom. Lisinopril and their complexes have been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS* and ΔG* were estimated using Coats and Redfern as well as Horowitz-Metzger equations.

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Author Biographies

M. Zaky, Zagazig University

Department of Chemistry, Faculty of Science

Mohamed Y. El-Sayed, 1. Zagazig University 2. Al Jouf University-Al Qurayate

  1. Department of Chemistry, Faculty of Science
  2. Faculty of Applied Medical Science

Samy M. El-Megharbel, 1. Zagazig University 2. Taif University

  1. Department of Chemistry, Faculty of Science
  2. Department of Chemistry, Faculty of Science

Sameh Abo Taleb, Zagazig University

Department of Chemistry, Faculty of Science

Moamen S. Refat, 1. Taif University, Sauidi Arabia 2. Port Said University, Egypt

  1. Department of Chemistry, Faculty of Science
  2. Department of Chemistry, Faculty of Science, Port Said

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Published

2017-10-12

Issue

Vol. 58 No. 2 (2014): Regular Issue

Section

Regular Articles

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