Synthesis of New Hispolon Derived Pyrazole Sulfonamides for Possible Antitubercular and Antimicrobial Agents

  • Hari Babu Bollikolla Acharya Nagarjuna University
  • V. S. Narasimha Raju Pericherla Natsol Laboratories Private Limited
  • jagan Acharya Nagarjuna University
  • V. Balaji Neduri Natsol Laboratories Private Limited
  • Chandra Mohan Kurmarayuni Acharya Nagarjuna University
  • V. Subbaraju Gottumukkala Natsol Laboratories Private Limited
Keywords: Hispolon, sulfonamides, hispolon pyrazole, antimicrobial activity, pyrazole sulfonamides, anti TB

Abstract

Abstract. A series of 10 new hispolonpyrazole sulfonamides were designed and synthesized using hispolons and 4-sulfonamide phenylhydrazine hydrochloride with better yields. The synthesized pyrazole sulfonamides were screened for anti-TB, anti-bacterial, and anti-fungal activities to compare the role sulfonamide moiety. Among them, 3a and 3b showed selective potent anti-tubercular nature (MIC 6.25µg/mL). Further, the antimicrobial studies of the compounds showed only compound 3b with a good inhibition zone on Staphylococcus aureus among other bacteria and fungi studied.

 

Resumen.Se prepararon 10 nuevas hispolon-pirazol-suklfonamidas con buenos rendimientos haciendo reaccionar hipolonas y el clorhidrato de 4-sulfonamidil-fenílhidrazina. Los productos obtenidos se probaron contra cepas de hongos y bacterias con especial interés en la tuberculosis, encontrando algunos derivados con actividades del orden de MIC 6.25µg/mL.

Author Biographies

Hari Babu Bollikolla, Acharya Nagarjuna University

Department of Chemistry

V. S. Narasimha Raju Pericherla, Natsol Laboratories Private Limited

II Floor, Research and Development Building, Ramky Commercial Hub

jagan, Acharya Nagarjuna University

Department of Chemistry

V. Balaji Neduri , Natsol Laboratories Private Limited

II Floor, Research and Development Building, Ramky Commercial Hub

Department of Chemistry, Acharya Nagarjuna University

Chandra Mohan Kurmarayuni, Acharya Nagarjuna University

Department of Chemistry

V. Subbaraju Gottumukkala , Natsol Laboratories Private Limited

II Floor, Research and Development Building, Ramky Commercial Hub

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Published
02-22-2021
Section
Regular Articles