Chemical Constituents of Senecio procumbens
Keywords:
Senecio procumbens, asteraceae, senecioneae, pyrrolizidine alkaloidsAbstract
Abstract. A chemical study of Senecio procumbens afforded the 12-membered macrocyclic diester pyrrolizidine alkaloids senecionine (1), senecivernine (2), retrorsine (3) and their N-oxides, together with 132-hydroxyphaeophytin a (4), caffeic acid methyl ester (5), and cacticin (6). The identification of these compounds was accomplished by comparison of their spectral features with those reported in literature. The structures of compounds 1, and those of the N-oxides of 1 and 3 were confirmed by comparison with authentic samples. In addition, the 1H and 13C NMR spectroscopies of 2 N-oxide are reported since they were not available in the literature.
Resumen. De un estudio químico de Senecio procumbens se aislaron los alcaloides pirrolizidínicos diésteres macrocíclicos de 12 miembros: senecionina (1), senecivernina (2), retrorsina (3) y sus N-óxidos, junto con 132-hidroxifeofitina a (4), cafeato de metilo (5) y cacticina (6). Estos metabolitos fueron identificados por comparación de sus datos espectroscópicos con los descritos. La estructura de 1, y de los N-óxidos de 1 y 3 fue confirmada por comparación con muestras auténticas. Adicionalmente se incluyen los datos de RMN de 1H y 13C del N-óxido de 2, los cuales no han sido descritos.
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