Coumarin Derivatives from Loeselia mexicana. Determination of the Anxiolytic Effect of Daphnoretin on Elevated Plus-maze
DOI:
https://doi.org/10.29356/jmcs.v51i4.1281Keywords:
Loeselia mexicana Brand, daphnoretin, 7-acetyldaphnoretin, 13C NMR chemical shift, elevated plus maze, anxietyAbstract
Abstract. The bis-coumarin daphnoretin (1) and its monomeric precursors scopoletin (3) and umbelliferone (4) were isolated for the first time from L. mexicana, a vegetal species used in Mexican traditional medicine. The unambiguous 13C NMR chemical shifts assignments of daphnoretin (1) and its acetyl derivative 2 were achieved through one-bond (gHMQC) and long-distance (gHMBC) heteronuclear correlations. The crude hydroalcoholic extract and pure daphnoretin 1 obtained from this plant, showed anxiolytic effect in male ICR mice exposed to elevated plus-maze. Different doses of daphnoretin (1) were not able to modify the spontaneous locomotor activity measured in the open field test. This is the first report regarding to the anxiolytic effect of daphnoretin (1).
Resumen. La bis-coumarina dafnoretina (1) y sus precursores monoméricos escopoletina (3) y umbelliferona (4) se aislaron por vez primera de la parte aérea de L. mexicana Brand, una especie vegetal usada en la medicina tradicional mexicana. Los desplazamientos químicos de RMN 13C de dafnoretina (1) y su derivado acetilado 2 se establecieron de manera inequívoca mediante experimentos de correlación heteronuclear (gHMQC y gHMBC). El extracto etanólico crudo y la dafnoretina (1) pura obtenidos de esta planta mostraron efecto ansiolítico en ratones machos ICR sometidos al experimento de laberinto elevado en forma de cruz. Los diferentes tramientos de dafnoretina (1) no modificaron la actividad motora espontánea medida con el método de campo abierto. Este es el primer estudio que describe el efecto ansiolítico de la dafnoretina (1).
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