Enzymatic Hydrolysis of N-protected 2-Hydroxymethylpiperidine Acetates
DOI:
https://doi.org/10.29356/jmcs.v52i3.1065Keywords:
liver acetone powder, 2-hydroxymethylpiperidine, biocatalysis, hydrolysisAbstract
Liver acetone powders (LAPs) were used as hydrolase sources to biocatalyze the hydrolysis of N-protected-2-hydroxymethylpiperidine acetates (N-Ts and N-Boc). Different reaction conditions were evaluated, like source of LAP (cat, guinea pig, chicken, dog, sheep, bovine, rat, mouse, pig and rabbit), proportion of cosolvent, type of cosolvent and pH.
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References
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2. Sánchez-Sancho, F.; Herrandón, B. Tetrahedron: Asymmetry 1998, 9, 1951-1965.
3. Adger, B.; Dyer, U.; Hutton, G; Woods, M. Tetrahedron Lett. 1996, 37, 6399-6402.
4. Scopes, D.I.C.; Hayes, N.F.; Bays, D.F.; Belton, D.; Brain, J.; Brown, D.S.; Judd, D.B.; McElroy, A.B.; Meerholz, C.A.; Naylos, A.; Hayes, A.G.; Sheehan, M.J.; Birch, P.J.; Tyers, M.B. J. Med. Chem. 1992, 35, 490-501.
5. a) Wasserman, H.H.; Rotello, V.M. J. Org. Chem. 1989, 54, 2785-2786. b) Che, S.H.; Horvath, R.F.; Joglar, J.; Fischer, M.J.; Danishefsky S.J. J. Org. Chem. 1991, 56, 5834-5845.
6. Bora, U.; Saikia, C. J.; Chetia, A.; Mishra, A. K.; Kumar, B.S.D.; Boruah, R.C. Tetrahedron Lett. 2003, 44, 9099-9102.
7. Basavaiah, D. Arkivoc 2001, 70-82.
8. Solís, A.; García, S.; Pérez, H.I.; Manjarrez, N.; Luna, H. Tetrahedron: Asymmetry 2008, 19, 549-553.
9. Shen, Z.; Lu, X.; Lei, A. Tetrahedron 2006, 62, 9237–9246.
10. Solís, A.; Pérez, H.I.; Manjarrez, N.; Luna, H.; Aquino, F; Nava, A. Rev. Mex. Cien. Farm. 2006, 37, 23-28.
11. Molander, G.A.; Romero, J. Tetrahedron 2005, 61, 2631–2643.
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2019-07-31
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