Evaluation of Some Plant-derived Secondary Metabolites Against Sensitive and Multidrug-resistant Mycobacterium tuberculosis
DOI:
https://doi.org/10.29356/jmcs.v53i2.1008Keywords:
Mycobacterium tuberculosis, antituberculosis activity, bioactive secondary metabolites, alkaloids, flavonoids, quinones, triterpenes, diterpenesAbstract
The results on the bioevaluation of thirty five plant-derived secondary metabolites against one sensitive and three multidrugresistant clinical isolates of Mycobacterium tuberculosis are reported. Results toward the sensitive strain showed that five products gave MIC values of 12.5 µg/mL: the alkaloids 6-methoxydihydrochelerytrine (2) and 6-methoxy-dihydrochelirubine (6), the flavanone pinostrobin (17), 1-hydroxy-benzoisochromanquinone (23) and 23-hydroxy-5a-lanosta7,9(11),24-triene-3-one (33). These were followed by the peracetylstrictosidine lactam (12) and the quinone aloe-emodin (24) which displayed MICs of 6.25 µg/mL. Finally, liriodenine (8) was the most active (MIC: 3.125 µg/mL) of all secondary metabolites. Results with the multidrug-resistant clinical isolates showed that 6-methoxy-dihydrochelirubine (6) was the most active (MIC: 12.5 µg/mL).
Downloads
References
2. Newton, S. M.; Lau, C.; Wright, C. W. Phytother. Res. 2000, 14, 303-322.
3. Copp, B. R. Nat. Prod. Rep. 2003, 20, 535-557.
4. Okunade, A. L.; Elvin-Lewis, M.P.F.; Lewis, W. H. Phytochemistry 2004, 65, 1017-1032.
5. Camacho, M. R.; Sánchez, B.; Quiroz, H.; Contreras, J. L.; Mata, R. J. Ethnopharm. 1991, 31, 383-389.
6. Camacho, M.R.; Mata, R.; Castañeda, P.; Kirby, G. C.; Warhurst, D. C.; Croft, S. L.; Phillipson, J. D. Planta Med. 2000; 66, 463468.
7. Camacho, M. R.; Kirby, G. C.; Warhurst, D. C.; Croft, S. L.; Phillipson, J. D. Planta Med. 2000, 66, 478-480.
8. Camacho, M. R.; Phillipson, J. D.; Croft, S. L.; Kirby, G. C.; Warhurst, D. C.; Solis, P.N. Phytochemistry 2001, 56, 203-210.
9. Camacho, M. R.; Phillipson, J. D.; Croft, S. L.; Rock, P.; Marshall, S. J.; Schiff, P. L. Jr. Phytother. Res. 2002, 16, 432-436.
10. Camacho, M. R.; Phillipson, J. D.; Croft, S. L.; Marley, D.; Kirby, G. C.; Warhurst, D. C. J. Nat. Prod. 2002, 65, 1457-1461.
11. Solis, P. N.; Wright, C. W.; Gupta, M. P.; Phillipson, J. D. Phytochemistry 1993, 33, 1117-1119.
12. Solis, P. N.; Lang´at, C.; Gupta, M. P.; Kirby, G. C.; Warhurst, D. C.; Phillipson, J. D. Planta Med. 1995, 61, 62-64.
13. Navarro, V.; Delgado, G. J. Ethnopharmacol. 1999, 66, 223-226. Navarro, V.; Rojas, G.; Delgado, G.; Lozoya, X. Arch. Med. Res. 1998, 29, 191-194.
14. Narváez-Mastache, J. M.; Garduño-Ramírez, M. L.; Álvarez, L.; Delgado, G. J. Nat. Prod. 2006, 69, 1687-1691. NarváezMastache, J. M.; Soto, C.; Delgado, G. Biol. Pharm. Bull. 2007, 30, 1503-1510
15. Collins, L.; Franzblau, S. G. Antimicrob. Agents Chemother. 1997; 41, 1004-0000.
16. Jiménez-Arellanes, A.; Meckes, M.; Ramírez, R.; Torres, J.; Luna-Herrera, J. Phytother. Res. 2003, 17, 903-938.
17. Wachter, G. A.; Valcic, S.; Flagg, M. L.; Franzblau, S. G.; Montenegro, G.; Suárez, E.; Timmermann, B. N. Phytomedicine 1999, 6, 341-345.
18. Caldwell, G. C.; Franzblau, S. G.; Suarez, E.; Timmermann, B. N. J. Nat. Prod. 2000; 63, 1611-1614.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
