Substituted Pyridopyrimidinones. Part 3. Synthesis of Some Novel Ether Derivatives of 4H-Pyrido[1,2-a]pyrimidin-4-one
DOI:
https://doi.org/10.29356/jmcs.v53i2.1005Keywords:
Pyrido[1,2-a]pyrimidinone, Ethers, Pyrazoles, Oxadiazolines, PyronesAbstract
A series of novel bis-heterocyclic ethers, containing 4Hpyrido[1,2-a]pyrimidin-4-one along with other five and six-membered heterocyclic rings, was obtained utilizing ethyl [(4-oxo-4Hpyrido[1,2-a]pyrimidin-2-yl)oxy]acetate (1), [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetic acid (2) and/or [(4-oxo-4H-pyrido[1,2a]pyrimidin-2-yl)oxy]acetohydrazide (3). Reaction of ester 1 with some ortho-hydroxy-aldehydes furnished the corresponding pyridopyrimidyloxypyrones. Reaction of ester 1 or acid 2 with 1,2-diamines led to some imidazoles. Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3.
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References
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3. Jeste, D. V.; Okamoto, A.; Napolitano, J.; Kane, J. M.; Martinez, R. A. Am. J. Psychiatry 2000, 157, 1150-1155.
4. Kapui, Z.; Varga, M.; Urban-Szabo, K.; Mikus, E.; Szabo, T.; Szeredi, J.; Batori, S.; Finance, O.; Armani, P. J. Pharmacol. Exper. Therap. 2003, 305, 451-459.
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13. Tomita, K. J. Pharm. Soc. Japan (Yakugaku Zasshi) 1951, 71, 1100-1112.
14. (a) Al-Soud, Y. A.; Al-Masoudi, N. A.; Loddo, R.; La Colla, P. Archiv. Pharm. 2008, 341, 365-369; (b) Al-Soud, Y. A. Heteroatom Chem. 2007, 18, 443-448; (c) Al-Soud, Y. A.; AlMasoudi, N. A.; Ferwanah, A. E.-R. Bioorg. Med. Chem. 2003, 11, 1701-1708.
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