essential oil; lavender; antimicrobial activity; bioactive compound; GC-MS; Mycobacterium smegmatis.
DOI:
https://doi.org/10.29356/jmcs.v58i4.52Keywords:
Citrus sinensis, GC-MS, Mycobacterium tuberculosis, anti-TB compoundsAbstract
Tuberculosis (TB) is a great cause of morbidity and mortality around the world. The increasing incidence of multidrug-resistant (MDR) Mycobacterium tuberculosis and co-infection TB-AIDS led to the need to develop new TB drugs, and plants could be a source of them. The hexane extract of Citrus sinensis with anti-TB activity was analyzed by GC-MS. This analysis showed the presence of 40 volatile components, including monoterpenes (81.74%), sesquiterpenes (1.32%), fatty acids (1.15%), and some other oxygenated non-aromatic compounds (15.73%). Some identified compounds were tested against M. tuberculosis H37Rv, and one clinical isolated MDR M. tuberculosis strain. Results showed that palmitic acid, decanal, caryophyllene oxide, and cis-limonene oxide contributed to the anti-TB activity of hexane extract of C. sinensis peel.
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References
Word Health Organization. Global Tuberculosis Report 2013.
Camacho-Corona, M.R.; Favela-Hernández, J.M.J.; González-Santiago, O.; Garza-González, E.; Molina-Salinas, G.M.; Said-Fernández, S.; Delgado, G.; Luna-Herrera, J. J. Mex. Chem. Soc. 2009, 53, 71-75.
Li, S.; Lo, C.Y.; Ho, C.T. J. Agric. Food. Chem. 2006, 54, 4176-4185.
Chen, Z.T.; Chu, H.L.; Chyau, C.C.; Chu, C.C.; Duh, P.D. Food Chem. 2012, 135, 2119-2127.
Al-Ashaal, H.A.; El-Sheltawy, S.T. Pharm. Biol. 2011, 49, 276-282.
Manderson, K.; Pinart, M.; Tuohy, K.M.; Grace, W.E.; Hotchkiss, A.T.; Widmer, W.; Yadhav, M.P.; Gibson, G.R.; Rastall, R.A. Appl. Environ. Microbiol. 2005, 71, 8383-8389.
Pittman, C.I.; Pendleton, S.; Bisha, B.; O'Bryan, C.A.; Belk, K.E.; Goodridge, L.; Crandall, P.G.; Ricke, S.C. J. Food. Sci. 2011, 76, M433-438.
Ribeiro, N.C.; da Camara, C.A.; Born, F. de S.; de Siqueira, H.A. Nat. Prod. Commun. 2010, 5, 1819-1822.
Lv, Y.X.; Zhao, S.P.; Zhang, J.Y.; Zhang, H.; Xie, Z.H.; Cai, G.M.; Jiang, W.H. Int. J. Biol. Macromol. 2012, 50, 1144-11450.
Parmar, H.S.; Kar, A. Biofactors 2007, 31, 17-24.
Murugan, K.; Mahesh, K.P.; Kovendan, K.; Amerasan, D.; Subrmaniam, J.; Hwang, J.S. Parasitol. Res. 2012, 11, 1757-1769.
Bagavan, A.; Rahuman, A.A.; Kamaraj, C.; Kaushik, N.K.; Mohanakrishnan, D.; Sahal, D. Parasitol. Res. 2011, 8, 1099-10109.
Camacho-Corona, M.R.; Ramírez-Cabrera, M.A.; González-Santiago, O.; Garza-González, E.; Palacios, I.; Luna-Herrera, J. Phytother. Res. 2008, 22, 82–85.
Araújo, C.P. Jr,; da Camara, C.A.; Neves, I.A.; Ribeiro, N.; Gomes, de Morales, M.M.; Botelho, P. de S. Nat. Prod. Commun. 2010, 5, 471-476.
Michaelakis, A.; Papachristos, A.; Kimbaris, G.; Koliopoulos, A.; Giatropolus, A.; Polissiou, M.G. Parasitol. Res. 2009, 105, 769-773.
Qiao, Y.; Xie, B.J.; Zhang, Y.; Zhang, Y.; Fan, G.; Yao, X.L.; Pan, S.Y. Molecules 2008, 13, 1333-1344.
Seidel, V.; Taylor, P. Int. J. Antimicrob. Agents 2004, 23, 613-619.
Sandoval-Montemayor, N.E.; García, A.; Elizondo-Treviño, E.; Garza-González, E.: Alvarez, L.; Camacho-Corona, M.R. Molecules 2012, 17, 11173-11184.
Kondo, E.; Kanai, K. Jpn. J. Med. Sci. Biol. 1976, 29, 25-37.
Kondo, E.; Kanai, K. Jpn. J. Med. Sci. Biol. 1977, 30, 171-178.
Bisignano, G.; Lagana, M.; Trombetta, D.; Arena, S.; Nostro, A.; Uccella, N.; Mazzanti, G.; Saija, A. FEMS Microbiol. Lett. 2001, 198, 9-13.
Kubo, I.; Fujita, K.; Nihei, K.; Kubo, A. J. Appl. Microbiol. 2004, 96, 693-699.
Kanokmedhakul, S.; Kanokmedhakul, K.; Lekphrom, R. J. Nat. Prod. 2007, 70, 1536-1538.
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