Cytotoxic Constituents from the Stem Bark of Alvaradoa amorphoides
DOI:
https://doi.org/10.29356/jmcs.v59i3.37Keywords:
Alvaradoa amorphoides, cytotoxic activity, antiproliferative activity, acetylenic compoundAbstract
The chemical study of Alvaradoa amorphoides led to the isolation of four major constituents: chrysophanol (1), β-sitosterol (2), atraric acid (3), and 17-octadecen-6-ynoic acid (4). All compounds were evaluated on in vitro cytotoxic and antiproliferative assays. Atraric acid and 17-octadecen-6-ynoic acid showed cytotoxic activity. Additionally, compound 4 exhibited cytotoxic activity showing a certain degree of selectivity against cancer cell lines.Downloads
References
Jemal A., Bray F., Center M. M., Ferlay J., Ward E., Forman D. CA. Cancer J. Clin. 2011, 61, 69-90.
Gottesman, M. Annu. Rev. Med. 2002, 53, 615-627.
Thomas, H.; Coley, H. M. Cancer Control 2003, 10, 159-165.
Newman, D. J.; Cragg, G. M. J. Nat. Prod. 2007, 70, 461-477.
Cragg, G.; Newman, D. J. Ethnopharmacol.2005, 100, 72-79.
Phifer, S. S.; Lee, D.;, Seo, E. K.; Kim, N. C.;, Graf, T. N.; Kroll, D. J.; Navarro, H. A.; Izydore, R. A.; Jimenez, F.; García, R.; Rose, W. C.; Fairchild, C. R.; Wild, R.; Soejarto, D. D.; Farnsworth, N. R.; Kinghorn, A. D.; Oberlies, N. H.; Wall, M. E.; Wani, M. C. J. Nat. Prod. 2007, 70, 954-961.
Osadao, R., El Libro del Judío o Medicina Doméstica, Descripción de las Virtudes de las Yerbas Medicinales de Yucatán. Additional notes of Dr. Andrew Heath de Zapata, Mérida, Yucatán, México, 1834, 20-255.
Ankli, A.; Heinrich, M.; Bork, P.; Wolfram, L.; Bauerfeind, P.; Brun, R.; Schmid, C.; Weiss, C.; Bruggisser, R.; Gertsch, J.; Wasescha, M.; Sticher, O. J. Ethnopharmacol. 2002, 79, 43-52.
Caamal-Fuentes, E.; Torres-Tapia, L. W.; Sima-Polanco, P.; Peraza-Sanchez, S. R.; Moo-Puc, R. J. Ethnopharmacol. 2011, 135, 719-734.
Soto de Villatoro, B.; Giral Gonzalez, F.; Polonsky, J.; Baskevitch-Varon, Z. Phytochemistry 1974, 13, 2018-2019.
Harding, W.; Henry, G.; Lewis, P.; Jacobs, H.; McLean, S.; Reynolds, W. J. Nat. Prod. 1999, 62, 98-101.
Schleich, S.; Papaioannou, M.; Baniahmad, A.; Matusch, R. Planta Med. 2006, 72, 547-551.
Pearl, M. B.; Kleiman, R.; Earle, F. R. Lipids. 1973, 8, 627-630.
Minto, R. E.; Blacklock, B. J. Prog. Lipid Res. 2008, 47, 233-306.
Li, X. C.; Jacob, M. R.; ElSohly, H. N.; Nagle, D. G.; Smillie, T. J.; Walker, L. A.; Clark, A. M. J. Nat. Prod. 2003, 66, 1132-1135.
Dembitsky, V. M. Lipids 2006, 41, 883-924.
García-Sosa, K.; Villareal-Álvarez, N.; Lübben, P.; Peña-Rodriguez, L. M. J. Mex. Chem. Soc. 2006, 50, 76-78.
Denizot, F.; Lang, R. J. Immunol. Methods 1986, 89, 271-277.
Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J. T.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107-1112.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
