A Green and Simple Protocol one-pot Biginelli Condensation using Dicalcium Phosphate as Reusable Catalyst

  • Zakaria Benzekri Ibn Tofaïl University
  • Redoua Benhdidou Ibn Tofaïl University
  • Sara Hamia Ibn Tofaïl University
  • Houda Serrar Ibn Tofaïl University
  • Said Boukhris Ibn Tofaïl University
  • Brahim Sallek Ibn Tofaïl University
  • Amina Hassikou Ibn Tofaïl University
  • Abdelaziz Souizi Ibn Tofaïl University
Keywords: Heterogeneous catalysis, Green process, Dicalcium phosphate, 3, 4-Dihydropyrimidin-2-ones, 4-Dihydropyrimidin-2-thiones

Abstract

Dicalcium phosphate dihydrate (DCPD) was used as a green and reusable catalyst in order to synthesized two important categories of heterocycles, 3,4-dihydropyrimidin-2-ones and 3,4-dihydropyrimidin-2-thiones. The advantages of our method are as follow: short reaction times, green process, reduced environmental hazards and high isolated yield of products.

Author Biographies

Zakaria Benzekri, Ibn Tofaïl University
Laboratory of Organic Chemistry, Organometallic and Theoretical. Faculty of Sciences
Redoua Benhdidou, Ibn Tofaïl University
Laboratory of Organic Chemistry, Organometallic and Theoretical. Faculty of Sciences
Sara Hamia, Ibn Tofaïl University
Laboratory of Organic Chemistry, Organometallic and Theoretical. Faculty of Sciences
Houda Serrar, Ibn Tofaïl University
Laboratory of Organic Chemistry, Organometallic and Theoretical. Faculty of Sciences
Said Boukhris, Ibn Tofaïl University
Laboratory of Organic Chemistry, Organometallic and Theoretical. Faculty of Sciences
Brahim Sallek, Ibn Tofaïl University
Laboratory of Agricultural Resources and Process Engineering. F Faculty of Sciences
Amina Hassikou, Ibn Tofaïl University
Laboratory of Organic Chemistry, Organometallic and Theoretical. Faculty of Sciences
Abdelaziz Souizi, Ibn Tofaïl University
Laboratory of Organic Chemistry, Organometallic and Theoretical. Faculty of Sciences
Published
2017-10-26