Toxicity Assessment of Structurally Relevant Natural Products from Mexican Plants with Antinociceptive Activity

Karina Martinez-Mayorga, Andrés F. Marmolejo-Valencia, Fernando Cortes-Guzman, Juan Carlos García-Ramos, Eric Iván Sánchez-Flores, Joaquín Barroso-Flores, Jose L. Medina-Franco, Baldomero Esquivel-Rodriguez

Abstract


UNIIQUIM database contains molecules from Mexican plants, one of the richest sources of bioactive molecules in the world. Here, we describe the chemical and toxicological profile of molecules with analgesic activity from UNIIQUIM. Most of the compounds are likely to interact with opioid receptors. The predicted acute toxicity is low and none is predicted mutagenic. Given the structural diversity, and biological and toxicity profiles, these molecules represent a new avenue in the search of molecules with antinociceptive activity.

Keywords


UNIIQUIM; traditional Mexican medicine; analgesics; nociception; toxicity profile.

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Copyright (c) 2017 Karina Martinez-Mayorga, Andrés F. Marmolejo-Valencia, Fernando Cortes-Guzman, Juan Carlos García-Ramos, Eric Iván Sánchez-Flores, Joaquín Barroso-Flores, Jose L. Medina-Franco, Baldomero Esquivel-Rodriguez

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Journal of the Mexican Chemical Society (J. Mex. Chem. Soc.) Vol 61, No 3 (2017). Quarterly publication (July-September). Edited and distributed by Sociedad Química de México, A.C. Barranca del Muerto 26, Col. Crédito Constructor, Del. Benito Juárez, C.P. 03940, Mexico City. Phone: +5255 56626837; +5255 56626823 Contact: soquimex@sqm.org.mx http://www.sqm.org.mx Editor-in-Chief: Ignacio González-Martínez. Indexed Journal. Certificate of reserved rights granted by the Instituto Nacional del Derecho de Autor (INDAUTOR): 04-2005-052710530600-102. Certificate of lawful title and content: Under procedure. ISSN-e granted by the Instituto Nacional del Derecho de Autor (INDAUTOR): Under Procedure. ISSN granted by the Instituto Nacional del Derecho de Autor (INDAUTOR): 1870-249X. Postal registration of printed matter deposited by editors or agents granted by SEPOMEX: IM09-0312 Copyright © Sociedad Química de México, A.C. Total or partial reproduction is prohibited without written permission of the right holder. The Figures/schemes quality and the general contents of this publication are full responsibility of the authors. Updated October 26th, 2017 by Adriana Vázquez (editorial assistant, e-mail: editor.jmcs@gmail.com), J. Mex. Chem. Soc., Sociedad Química de México, A.C.